Programs as Polypeptides

We describe a visual programming language for defining behaviors manifested by reified actors in a 2D virtual world that can be compiled into programs comprised of sequences of combinators that are themselves reified as actors. This makes it possible to build programs that build programs from components of a few fixed types delivered by diffusion using processes that resemble chemistry as much as computation.Comment: in European Conference on Artificial Life (ECAL '15), York, UK, 201

Population Viability Analysis for the Leopard Darter(Percidae: Percina pantherina)

Chapter II of this thesis is in the format for publication in the journal Conservation Biology. The work was funded by the United States National Biological Service and the Oklahoma cooperative Fish and wildlife Research Unit

Treatment with patiromer decreases aldosterone in patients with chronic kidney disease and hyperkalemia on renin-angiotensin system inhibitors

Elevated serum aldosterone can be vasculotoxic and facilitate cardiorenal damage. Renin-angiotensin system inhibitors reduce serum aldosterone levels and/or block its effects but can cause hyperkalemia. Patiromer, a nonabsorbed potassium binder, decreases serum potassium in patients with chronic kidney disease on renin-angiotensin system inhibitors. Here we examined the effect of patiromer treatment on serum aldosterone, blood pressure, and albuminuria in patients with chronic kidney disease on renin-angiotensin system inhibitors with hyperkalemia (serum potassium 5.1–6.5 mEq/l). We analyzed data from the phase 3 OPAL-HK study (4-week initial treatment phase of 243 patients; 8-week randomized withdrawal phase of 107 patients). In the treatment phase, the (mean ± standard error) serum potassium was decreased concordantly with the serum aldosterone (−1.99 ± 0.51 ng/dl), systolic/diastolic blood pressure (−5.64 ± 1.04 mm Hg/−3.84 ± 0.69 mm Hg), and albumin-to-creatinine ratio (−203.7 ± 54.7 mg/g), all in a statistically significant manner. The change in the plasma renin activity (−0.44 ± 0.63 μg/l/hr) was not significant. In the withdrawal phase, mean aldosterone levels were sustained with patiromer (+0.23 ± 1.07 ng/dl) and significantly increased with placebo (+2.78 ± 1.25 ng/dl). Patients on patiromer had significant reductions in mean systolic/diastolic blood pressure (−6.70 ± 1.59/−2.15 ± 1.06 mm Hg), whereas those on placebo did not (−1.21 ± 1.89 mm Hg/+1.72 ± 1.26 mm Hg). Significant changes in plasma renin activity were found only in the placebo group (–3.90 ± 1.41 μg/l/hr). Thus, patiromer reduced serum potassium and aldosterone levels independent of plasma renin activity in patients with chronic kidney disease and hyperkalemia on renin-angiotensin system inhibitors

Incidents of Snake Fungal Disease caused by the Fungal Pathogen Ophidiomyces ophidiicola in Texas

The pathogen Ophidiomyces ophidiicola, widely known as the primary cause of snake fungal disease (SFD), has been detected in Texas’s naïve snakes. Our team set out to characterize O. ophidiicola’s spread in eastern Texas. From December 2018 until November 2021, we sampled and screened with ultraviolet (UV) light 176 snakes across eastern Texas and detected 27. O. ophidiicola’s positive snakes using qPCR and one snake in which SFD was confirmed via additional histological examination. Upon finding the ribbon snake with a clear clinical display, we isolated and cultured what we believe to be the first culture from Texas. This cultured O. ophidiicola TX displays a ring halo formation when grown on a solid medium and cellular autofluorescence as expected. Imaging reveals that individual cells within the septated hyphae branches have a distinct nucleus separation from neighboring cells. Overall, we have found over 1/10 snakes that may be infected in East Texas, which gives credence to the onset of SFD in Texas. These results add to the progress of the disease across the continental United States

Toward Head-Worn Displays for Equivalent Visual Operations

The Next Generation Air Transportation System represents an envisioned transformation to the U.S. air transportation system that includes an "equivalent visual operations" (EVO) concept, intended to achieve the safety and operational tempos of Visual Flight Rules (VFR) operations independent of visibility conditions. Today, Federal Aviation Administration regulations provide for the use of an Enhanced Flight Visual System (EFVS) as "operational credit" to conduct approach operations below traditional minima otherwise prohibited. An essential element of an EFVS is the Head-Up Display (HUD). NASA has conducted a substantial amount of research investigating the use of HUDs for operational landing "credit", and current efforts are underway to enable manually flown operations as low as 1000 feet Runway Visual Range (RVR). Title 14 CFR 91.175 describes the use of EFVS and the operational credit that may be obtained with airplane equipage of a HUD combined with Enhanced Vision (EV) while also offering the potential use of an equivalent display in lieu of the HUD. A Head-Worn Display (HWD) is postulated to provide the same, or better, safety and operational benefits as current HUD-equipped aircraft but for potentially more aircraft and for lower cost. A high-fidelity simulation was conducted that examined the efficacy of HWDs as "equivalent" displays. Twelve airline flight crews conducted 1000 feet RVR approach and 300 feet RVR departure operations using either a HUD or HWD, both with simulated Forward Looking Infra-Red cameras. The paper shall describe (a) quantitative and qualitative results, (b) a comparative evaluation of these findings with prior NASA HUD studies, and (c) describe current research efforts for EFVS to provide for a comprehensive EVO capability

Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation

<p>Abstract</p> <p>Background</p> <p>The rising epidemic of obesity is associated with cognitive decline and is considered as one of the major risk factors for neurodegenerative diseases. Neuroinflammation is a critical component in the progression of several neurological and neurodegenerative diseases. Increased metabolic flux to the brain during overnutrition and obesity can orchestrate stress response, blood-brain barrier (BBB) disruption, recruitment of inflammatory immune cells from peripheral blood and microglial cells activation leading to neuroinflammation. The lack of an effective treatment for obesity-associated brain dysfunction may have far-reaching public health ramifications, urgently necessitating the identification of appropriate preventive and therapeutic strategies. The objective of our study was to investigate the neuroprotective effects of <it>Momordica charantia </it>(bitter melon) on high-fat diet (HFD)-associated BBB disruption, stress and neuroinflammatory cytokines.</p> <p>Methods</p> <p>C57BL/6 female mice were fed HFD with and without bitter melon (BM) for 16 weeks. BBB disruption was analyzed using Evans blue dye. Phosphate-buffered saline (PBS) perfused brains were analyzed for neuroinflammatory markers such as interleukin-22 (IL-22), IL-17R, IL-16, NF-κB1, and glial cells activation markers such as Iba1, CD11b, GFAP and S100β. Additionally, antioxidant enzymes, ER-stress proteins, and stress-resistant transcription factors, sirtuin 1 (Sirt1) and forkhead box class O transcription factor (FoxO) were analyzed using microarray, quantitative real-time RT-PCR, western immunoblotting and enzymatic assays. Systemic inflammation was analyzed using cytokine antibody array.</p> <p>Results</p> <p>BM ameliorated HFD-associated changes in BBB permeability as evident by reduced leakage of Evans blue dye. HFD-induced glial cells activation and expression of neuroinflammatory markers such as NF-κB1, IL-16, IL-22 as well as IL-17R were normalized in the brains of mice supplemented with BM. Similarly, HFD-induced brain oxidative stress was significantly reduced by BM supplementation with a concomitant reduction in FoxO, normalization of Sirt1 protein expression and up-regulation of Sirt3 mRNA expression. Furthermore, plasma antioxidant enzymes and pro-inflammatory cytokines were also normalized in mice fed HFD with BM as compared to HFD-fed mice.</p> <p>Conclusions</p> <p>Functional foods such as BM offer a unique therapeutic strategy to improve obesity-associated peripheral inflammation and neuroinflammation.</p

Strong Shift Equivalence of C∗C^*-correspondences

We define a notion of strong shift equivalence for $C^*$-correspondences and show that strong shift equivalent $C^*$-correspondences have strongly Morita equivalent Cuntz-Pimsner algebras. Our analysis extends the fact that strong shift equivalent square matrices with non-negative integer entries give stably isomorphic Cuntz-Krieger algebras.Comment: 26 pages. Final version to appear in Israel Journal of Mathematic